← All baskets
Health Thematic basket

GLP-1 Pressure

Business models the market discounts when GLP-1 adoption accelerates: indulgent packaged food and drinks, alcohol, quick-service restaurants, and the medical devices treating obesity comorbidities (sleep apnea, diabetes hardware, dialysis). A monitoring list for underperformance — not a recommendation in either direction.

17 stocks · S&P 500 universeEqual-weighted · monthly rebalance2026-10-21 · close
1 day-1.0%basket return
20 days+3.4%basket return
20 days vs S&P 500+2.7%relative return
Year to date+0.2%basket return

Performance

Follow the theme against the wider market.

Period
-11.3%-6.8%-2.2%+2.3%+6.9%2026-07-282026-10-21
GLP-1 PressureS&P 500

Series before each basket's creation date are a backtest of the membership as of creation; live tracking starts at creation.

Return1 day5 days20 days60 daysMTDYTD1 year
Basket-1.0%+2.5%+3.4%-3.4%+6.9%+0.2%-4.8%
vs S&P 500-1.6%+2.0%+2.7%-7.7%+5.3%-12.0%-17.8%

Risk statistics

Period · 1y

1y · 2025-10-21 – 2026-10-21 · 252 / 252 sessions

Sharpe ratio-0.20Annualized · 0% risk-free rate
Sortino ratio-0.29Annualized · 0% downside target
Historical volatility17.2%Annualized · daily log returns

Basket total returns · Annualized using 252 trading sessions · 0% risk-free rate and downside target. As of 2026-10-21 · close.

How these statistics are calculated

Risk methodology

Sharpe: average daily simple return divided by its sample standard deviation, multiplied by √252. The risk-free rate is assumed to be 0%; this is not a cash-adjusted ratio.

Sortino: average daily simple return divided by downside deviation, multiplied by √252. Downside deviation is the square root of the average squared shortfall below 0%, counting all sessions, including zeros for gains.

Historical volatility: √(252 × average squared daily log return), matching the Vol page’s realized-volatility convention. This differs from the sample standard deviation used in Sharpe.

Each period requires complete history and at least 5 sessions. MTD and YTD follow the calendar; 1y is 252 sessions. Missing data or an undefined ratio displays — with a reason. Short periods can produce unstable ratios; intraday snapshots include a partial session. History before this basket’s creation is backtested. If a new basket has no stored daily return series yet, estimates from its rounded published chart levels are marked ≈.

Full basket risk methodology →

Inside the basket · 17 stocks

Current members and the reasoning behind each inclusion. Returns are for individual holdings.

Why it’s includedAdded
STZConstellation BrandsBeer/wine/spirits — alcohol-pullback risk-0.5%+3.6%+13.3%-2.3%2026-06-11
RMDResMedSleep apnea devices — the original GLP-1 casualty trade+0.3%+4.6%+10.8%+3.0%2026-06-11
KDPCarbonated soft drinks-0.5%+4.1%+9.3%+27.0%2026-06-11
TAPBeer volumes — GLP-1 users drink less-1.8%+2.2%+7.8%-12.5%2026-06-11
YUMYum! BrandsQSR portfolio (KFC, Taco Bell, Pizza Hut)-0.2%+3.1%+7.5%+1.4%2026-06-11
BF-BBrown–FormanSpirits — alcohol-pullback risk+0.3%-0.4%+7.2%+11.0%2026-06-11
DPZDomino'sPizza delivery — indulgence occasions-1.6%+5.2%+5.0%-24.0%2026-06-11
SJMJ.M. Smucker Company (The)Sweet snacking (Hostess) plus spreads-1.4%+4.9%+4.4%+34.7%2026-06-11
PODDInsulet CorporationInsulin pumps, same debate-0.5%+5.9%+4.0%-50.1%2026-06-11
PEPPepsiCoFrito-Lay salty snacks plus sugary drinks+0.5%+4.2%+3.5%-3.3%2026-06-11
MCDMcDonald'sQSR traffic under appetite suppression-0.1%+3.3%+3.3%-17.8%2026-06-11
MDLZMondelez InternationalSnacking exposure-2.0%+0.3%+3.0%+19.6%2026-06-11
HSYHershey Company (The)Confectionery volume risk-1.0%+2.2%-0.4%-5.7%2026-06-11
KHCThe Kraft Heinz CompanyProcessed food skew-1.4%+3.5%-1.2%+2.0%2026-06-11
DVADaVitaDialysis: long-tail kidney-disease exposure+0.8%-2.2%-3.5%+55.6%2026-06-11
GISGeneral MillsPackaged food basket weight-2.6%+1.4%-7.3%-25.1%2026-06-11
DXCMDexcomCGM: diabetes incidence debate-6.4%-3.8%-8.5%+20.9%2026-06-11

No longer in the selected universe; awaiting membership review: TAP.

How this basket is built

Equal-weighted; monthly rebalance, buy-and-hold between rebalances; dated membership changes reset the target weights.

Tracked since 2026-06-11. Membership decisions are documented below.

Read the methodology →

Reading the returns

Basket returns include dividends. “vs S&P 500” compares the basket’s compounded growth with the benchmark’s. Green means positive; red means negative.

Membership history & changes

Membership history

  • drop

    CAG and CPB left the S&P 500 (index demotions, caught by the pipeline's constituent check). Both remain FW 3000 constituents and move to broad entries, as ZION, MOH, and MHK did — the FW 3000 version is unchanged, the S&P version thins to 17. Packaged-food demotions from the index are the GLP-1 pressure thesis playing out in slow motion.

  • expand

    FW 3000 pass: added UTZ, JJSF, WING, EAT, TXRH, TNDM, INSP — names outside the S&P 500 but inside our broad universe; they count only in the FW 3000 version of this basket. Effective-dated to creation so the broad backtest covers the full set. The S&P 500 basket is unchanged.

  • expand

    Widening pass: added the rest of indulgent food and drink (CAG, SJM, PEP, KDP), the alcohol leg (TAP, STZ, BF-B), and quick-service restaurants (MCD, YUM, DPZ). No clean inverse-theme ETF exists; the basket stays a watchlist. New members are effective-dated to basket creation so the backtest and the reference correlation cover the widened set (the basket was one day old, with no meaningful live history to restate).

  • create

    Pressured names only; LLY alone is not a basket. Monitoring list, not a recommendation.

The daily brief, by emailUnusual moves, leadership, breadth, and the factor table — one email at every US market close, plus a Saturday week-in-review. Read a sample brief →
Free. Unsubscribe anytime. Your email is never shared.